Complexation of several drugs with water-soluble cyclodextrin polymer.
نویسندگان
چکیده
The complex-forming abilities of a water-soluble ƒÀ-cyclodextrin-epichlorohydrin polymer (CDPS) and two different molecular weight fractions of CDPS were studied and compared with those of ƒÀ-cyclodextrin (ƒÀ3-CyD) and dimethyl-ƒÀ-cyclodextrin (DM-ƒÀ-CyD). CDPS was separated into two main fractions by gel chromatography. CDPS and its fractions formed inclusion compounds with several drugs and these complexes were readily soluble. The lowmolecular-weight fraction formed rather stable complexes with small guest molecules. The highmolecular-weight fraction was found to be more efficient in binding larger substrates.
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 35 1 شماره
صفحات -
تاریخ انتشار 1987